Definition, acronyms, nomenclature, and classification of angioedema (DANCE): AAAAI, ACAAI, ACARE, and APAAACI DANCE consensus

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • Avner Reshef - , Barzilai Medical Center (Author)
  • Thomas Buttgereit - , Charité – Universitätsmedizin Berlin, Fraunhofer Institute for Translational Medicine and Pharmacology (Author)
  • Stephen D. Betschel - , University of Toronto (Author)
  • Teresa Caballero - , Universidad Autónoma de Madrid, Russian Ministry of Health (Author)
  • Henriette Farkas - , Semmelweis University (Author)
  • Anete S. Grumach - , Fundação Universitaria do ABC, Faculdade de Medicina do ABC (Author)
  • Michihiro Hide - , Hiroshima University (Author)
  • Ankur K. Jindal - , Postgraduate Institute of Medical Education and Research (Author)
  • Hilary Longhurst - , The University of Auckland (Author)
  • Jonathan Peter - , University of Cape Town (Author)
  • Marc A. Riedl - , University of California at San Diego (Author)
  • Yuxiang Zhi - , Peking Union Medical College (Author)
  • Werner Aberer - , Medical University of Graz (Author)
  • Mohamed Abuzakouk - , Cleveland Clinic Abu Dhabi (Author)
  • Tariq Al Farsi - , Royal Hospital Oman (Author)
  • Nashat Al Sukaiti - , Royal Hospital Oman (Author)
  • Mona Al-Ahmad - , Kuwait University (Author)
  • Sabine Altrichter - , Kepler University Hospital (Author)
  • Emel Aygören-Pürsün - , University Hospital Frankfurt (Author)
  • Maria Luisa Baeza - , Hospital General Universitario Gregorio Marañon (Author)
  • Noemi Anna Bara - , Romanian Hereditary Angioedema Expertise Centre (Author)
  • Andrea Bauer - , Department of Dermatology, University Hospital Carl Gustav Carus Dresden (Author)
  • Jonathan A. Bernstein - , University of Cincinnati (Author)
  • Isabelle Boccon-Gibod - , National Reference Center of Angioedema CREAK (Author)
  • Hanna Bonnekoh - , Charité – Universitätsmedizin Berlin, Fraunhofer Institute for Translational Medicine and Pharmacology (Author)
  • Laurence Bouillet - , National Reference Center of Angioedema CREAK, CHU de Grenoble (Author)
  • Zenon Brzoza - , University of Opole (Author)
  • Anette Bygum - , Odense University Hospital, University of Southern Denmark (Author)
  • Oscar Calderon - , San Isidro (Author)
  • Regis de Albuquerque Campos - , Universidade Federal da Bahia (Author)
  • Freya Helena Campos Romero - , Hospital Central Sur Alta Especialidad (Author)
  • Mauro Cancian - , Azienda Ospedaliera di Padova (Author)
  • Herberto Jose Chong-Neto - , Universidade Federal do Paraná (Author)
  • George Christoff - , Excelsior Medical Centre, Medical University Sofia (Author)
  • Stefan Cimbollek - , Hospital Universitario Virgen del Rocio (Author)
  • Danny M. Cohn - , University of Amsterdam (Author)
  • Timothy Craig - , Pennsylvania State University (Author)
  • Inna Danilycheva - , Russian Ministry of Health (Author)
  • Razvigor Darlenski - , Trakia University (Author)
  • Aurélie Du-Thanh - , CHU Montpellier (Author)
  • Luis Felipe Ensina - , Federal University of São Paulo (Author)
  • Daria Fomina - , Moscow Healthcare Department (Author)
  • Luz Fonacier - , New York University (Author)
  • Atsushi Fukunaga - , Osaka Medical and Pharmaceutical University (Author)
  • Asli Gelincik - , Istanbul University (Author)
  • Pedro Giavina-Bianchi - , Universidade de São Paulo (Author)
  • Kiran Godse - , D Y Patil Group (Author)
  • Mark Gompels - , North Bristol NHS Trust (Author)
  • Margarida Goncalo - , University of Coimbra (Author)
  • Maia Gotua - , David Tvildiani Medical University (Author)
  • Guillermo Guidos-Fogelbach - , Instituto Politécnico Nacional (Author)
  • Mar Guilarte - , Vall d'Hebron Research Institute (VHIR) (Author)
  • Alicja Kasperska-Zajac - , Medical University of Silesia in Katowice (Author)
  • Constance H. Katelaris - , Western Sydney University (Author)
  • Tamar Kinaciyan - , Medical University of Vienna (Author)
  • Pavel Kolkhir - , Charité – Universitätsmedizin Berlin, Fraunhofer Institute for Translational Medicine and Pharmacology (Author)
  • Kanokvalai Kulthanan - , Mahidol University (Author)
  • Marcin Kurowski - , Medical University of Łódź (Author)
  • Elena Latysheva - , Russian Ministry of Health, Pirogov Russian National Research Medical University (Author)
  • Antti Lauerma - , Hospital District of Helsinki and Uusimaa (Author)
  • David Launay - , Université de Lille (Author)
  • Ramon Lleonart - , University Hospital of Bellvitge (Author)
  • William Lumry - , AARA Research Center (Author)
  • Alejandro Malbran - , Unidad de Alergia, Asma e Inmunología Clínica (Author)
  • Ramzy Mohammed Ali - , Hamad Medical Corporation (Author)
  • Iman Nasr - , Royal Hospital Oman (Author)
  • Sandra Nieto-Martinez - , Instituto Nacional de Pediatria (Author)
  • Claudio Parisi - , Hospital Italiano de Buenos Aires (Author)
  • Ruby Pawankar - , Nippon Medical School (Author)
  • Macarena Piñero-Saavedra - , Centro Hospitalar do Algarve (Author)
  • Todor A. Popov - , Medical University Sofia (Author)
  • Grzegorz Porebski - , Jagiellonian University in Kraków (Author)
  • Alicia Prieto Garcia - , Hospital General Universitario Gregorio Marañon (Author)
  • Polina Pyatilova - , Charité – Universitätsmedizin Berlin, Fraunhofer Institute for Translational Medicine and Pharmacology (Author)
  • Michael Rudenko - , London Allergy and Immunology Centre (Author)
  • Bulent Enis Sekerel - , Hacettepe University (Author)
  • Faradiba Sarquis Serpa - , Vitória (Author)
  • Farrukh Sheikh - , Chughtai Medical Center (Author)
  • Frank Siebenhaar - , Charité – Universitätsmedizin Berlin, Fraunhofer Institute for Translational Medicine and Pharmacology (Author)
  • Angèle Soria - , Hopital Tenon (Author)
  • Maria Staevska - , Medical University Sofia (Author)
  • Petra Staubach - , University Medical Center Mainz (Author)
  • Marcin Stobiecki - , Jagiellonian University in Kraków (Author)
  • Simon Francis Thomsen - , University of Copenhagen (Author)
  • Massimo Triggiani - , University of Salerno (Author)
  • Anna Valerieva - , Medical University Sofia (Author)
  • Solange Valle - , Universidade Federal do Rio de Janeiro (Author)
  • Nguyen Van Dinh - , Vinmec Healthcare System (Author)
  • Carolina Elisa Vera Ayala - , Charité – Universitätsmedizin Berlin, Fraunhofer Institute for Translational Medicine and Pharmacology (Author)
  • Anna Zalewska-Janowska - , Medical University of Łódź (Author)
  • Andrea Zanichelli - , University of Milan, IRCCS Policlinico San Donato (Author)
  • Markus Magerl - , Charité – Universitätsmedizin Berlin, Fraunhofer Institute for Translational Medicine and Pharmacology (Author)
  • Marcus Maurer - , Charité – Universitätsmedizin Berlin, Fraunhofer Institute for Translational Medicine and Pharmacology (Author)

Abstract

BACKGROUND: Angioedema (AE) manifests with intermittent, localized, self-limiting swelling of the subcutaneous and/or submucosal tissue. AE is heterogeneous, can be hereditary or acquired, may occur only once or be recurrent, may exhibit wheals or not, and may be due to mast cell mediators, bradykinin, or other mechanisms. Several different taxonomic systems are currently used, making it difficult to compare the results of studies, develop multicenter collaboration, and harmonize AE treatment.

OBJECTIVE: We developed a consensus on the definition, acronyms, nomenclature, and classification of AE (DANCE).

METHODS: The initiative involved 91 experts from 35 countries and was endorsed by 53 scientific and medical societies, and patient organizations. A consensus was reached by online discussion and voting using the Delphi process over a period of 16 months (June 2021 to November 2022).

RESULTS: The DANCE initiative resulted in an international consensus on the definition, classification, and terminology of AE. The new consensus classification features 5 types and endotypes of AE and a harmonized vocabulary of abbreviations/acronyms.

CONCLUSION: The DANCE classification complements current clinical guidelines and expert consensus recommendations on the diagnostic assessment and treatment of AE. DANCE does not replace current clinical guidelines, and expert consensus algorithms and should not be misconstrued in a way that affects reimbursement of medicines prescribed by physicians using sound clinical judgment. We anticipate that this new AE taxonomy and nomenclature will harmonize and facilitate AE research and clinical studies, thereby improving patient care.

Details

Original languageEnglish
Pages (from-to)398-411.e1
JournalJournal of Allergy and Clinical Immunology
Volume154
Issue number2
Publication statusPublished - Aug 2024
Peer-reviewedYes

External IDs

Scopus 85193505596
ORCID /0000-0002-4411-3088/work/169643518

Keywords

Keywords

  • acronyms, Angioedema, classification, terminology, types