Deep learning based treatment remission prediction to transcranial direct current stimulation in bipolar depression using EEG power spectral density

Research output: Contribution to journalLetterContributedpeer-review

Contributors

  • Jijomon Chettuthara Moncy - , University of East London (Author)
  • Wenyi Xiao - , University of East London (Author)
  • Rachel D. Woodham - , University of East London (Author)
  • Ali Reza Ghazi-Noori - , University of East London (Author)
  • Hakimeh Rezaei - , Department of Psychiatry and Psychotherapy, University of East London (Author)
  • Elvira Bramon - , University College London (Author)
  • Philipp Ritter - , Department of Psychiatry and Psychotherapy (Author)
  • Michael Bauer - , King's College London (KCL) (Author)
  • Allan H. Young - , King's College London (KCL), University of Oxford, South London and Maudsley NHS Foundation Trust (Author)
  • Yong Fan - , University of Pennsylvania Perelman School of Medicine (Author)
  • Cynthia H.Y. Fu - , University of East London, King's College London (KCL) (Author)

Abstract

Bipolar disorder is characterized by marked changes in mood and activity levels and is a leading cause of disability worldwide. We sought to investigate the application of deep learning methods to electroencephalogram (EEG) signals to predict clinical remission after 6 weeks of home-based transcranial direct current stimulation (tDCS) treatment. Pre-treatment resting-state EEG acquired from 21 bipolar participants was used for this work. A hybrid 1DCNN and GRU model, with input from power spectral density values of theta, beta and gamma frequency bands of the AF7 and TP10 electrodes, achieved a treatment remission prediction accuracy of 78.5% (sensitivity 81.4%, specificity 74.64%).

Details

Original languageEnglish
Article number112115
JournalPsychiatry Research - Neuroimaging
Volume357
Publication statusPublished - Apr 2026
Peer-reviewedYes

External IDs

PubMed 41478240
ORCID /0000-0002-2666-859X/work/203814157

Keywords

Keywords

  • Bipolar depression, Deep learning, EEG, Power spectral density, Prediction treatment remission, Predictors, tDCS