Cure of neuroendocrine carcinoma by peptide receptor radionuclide therapy
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
Peptide receptor radionuclide therapy provides a therapeutic option for neuroendocrine carcinoma. However, therapy response is often limited. A 53-year-old woman with known liver and bone metastases from a pancreatic neuroendocrine carcinoma was treated using 3.24 GBq (87 mCi) Y-90 1,4,7,10-tetraazacyclododecane-4,7,10-tricarboxy-methyl-1-yl-acety-D-Phe-Try- octreotide (DOTATOC). Follow-up investigation 4 months later demonstrated complete normalization of Ga-68 DOTATOC imaging. Normal FDG imaging ruled out dedifferentiation of the tumor as an explanation for the negative receptor imaging. Meanwhile, the woman is alive without evidence of disease, 12 months after therapy, suggesting complete cure without any limitations to survival.
Details
Original language | English |
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Pages (from-to) | 690-691 |
Number of pages | 2 |
Journal | Clinical nuclear medicine |
Volume | 33 |
Issue number | 10 |
Publication status | Published - Oct 2008 |
Peer-reviewed | Yes |
External IDs
PubMed | 18806569 |
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Keywords
ASJC Scopus subject areas
Keywords
- Lu-177 DOTATATE, Neuroendocrine carcinoma, Peptide receptor radionuclide therapy, Y-90 DOTATOC