How can culture help explain persistent cross-country differences in innovation and entrepreneurship? This overview of cross-cultural innovation/entrepreneurship research draws on the most prominent cultural frameworks (by Hofstede, Schwartz, GLOBE, and Gelfand and colleagues). After outlining similarities and differences between these frameworks, I discuss theoretical perspectives of how culture shapes innovation/entrepreneurship (culture fit, culture misfit, cultural social support, and culture as a boundary condition) and give an overview of empirical research on culture and innovation/entrepreneurship. I conclude by outlining opportunities and best practices for future research and practical implications.