CRBP-TS - evaluation of a home-based training and health care program for colorectal, breast, and prostate cancer using telemonitoring and self-management: study protocol for a randomized controlled trial

Research output: Contribution to journalResearch articleContributedpeer-review


  • Roberto Falz - , Leipzig University (Author)
  • René Thieme - , Leipzig University (Author)
  • Uwe Tegtbur - , Hannover Medical School (MHH) (Author)
  • Christian Bischoff - , Leipzig University (Author)
  • Christian Leps - , Leipzig University (Author)
  • Peter Hillemanns - , Hannover Medical School (MHH) (Author)
  • Kay Kohlhaw - , Sana Clinics Group (Author)
  • Jürgen Klempnauer - , Hannover Medical School (MHH) (Author)
  • Florian Lordick - , Leipzig University (Author)
  • Jens Uwe Stolzenburg - , Leipzig University (Author)
  • Bahriye Aktas - , Leipzig University (Author)
  • Jürgen Weitz - , Department of Visceral, Thoracic and Vascular Surgery (Author)
  • Ulrich Bork - , Department of Visceral, Thoracic and Vascular Surgery (Author)
  • Pauline Wimberger - , Department of Gynecology and Obstetrics (Author)
  • Christian Thomas - , Department of Urology (Author)
  • Ronald Biemann - , Leipzig University (Author)
  • Boris Jansen-Winkeln - , Leipzig University (Author)
  • Antina Schulze - , Leipzig University (Author)
  • Ines Gockel - , Leipzig University (Author)
  • Martin Busse - , Leipzig University (Author)


Background: Physical training is recommended in various national and international guidelines for patients with cancer. Observational studies have shown that physical activity leads to reduced recurrence and mortality rates by 20–40% in colorectal, breast, and prostate cancer. Despite existing evidence, a systematic care structure is still lacking. The primary aim of this study is to implement and evaluate an online training platform to strengthen physical performance and patient empowerment after cancer surgery. Methods: The evaluation will be conducted as a prospective multicenter randomized controlled trial with three subgroups (colorectal-, breast-, and prostate cancer). Each group will include 100 patients (total 300 patients including dropouts; clinical stages T1–3 and/or N+; M0 after surgery intervention) and the primary endpoint (13% increase in the maximal oxygen consumption during exercise) will be examined. The intervention group will receive a 6-month home-based online training (2–3 times per week strength-endurance training using video presentations), bidirectional activity feedback information, online communication, and online counseling. The control group (usual care) will be advised lifestyle improvement. In-hospital testing will be performed before, during, and after the intervention. In addition to cardiopulmonary capacity, tumor specific diagnostics (liquid biopsy, depression and fatigue assessment, metabolic and endothelial screening) will be applied. Discussion: Due to the increasing incidence of cancer, associated with considerable mortality, morbidity and impaired quality of life, there is an imperative requirement for improved cancer care, of which structured physical training may become an integral component. Trial registration: DRKS-ID: DRKS00020499; Registered 17 March 2020.


Original languageEnglish
Article number15
JournalBMC Sports Science, Medicine and Rehabilitation
Issue number1
Publication statusPublished - Dec 2021


Sustainable Development Goals


  • Cancer, Counseling, Home-based exercise, Oxygen uptake