Speed and efficiency in transportation have increased through the developingtechnology. Developments in the transportation sector have made it possible to reach manypoints of the world in less than a day. However, if there is a disaster like a pandemic, globaltransportation networks may contain significant threats. This is because transportation time isfaster than the incubation time of many diseases, even on long-distance journeys. Consideringthe past experiences, it has been observed that epidemic diseases have affected the wholeworld by first spreading from global transportation networks then from central transportationpoints to cities and rural areas.Cities are regions that host high population and various functions. Providing the citizenswith the most proper solutions to access to the urban services is also an important issue in thefield of transportation. Especially in metropolises, transporting mass groups of people at oncevia integrated transportation systems in order to ensure speed and efficiency is an inevitablerequirement to provide sustainable urban transportation services. The basis of this is thetransit-oriented development (TOD) policies in public transportation systems. However, thetransportation networks connected with the transfer transportation points in the cities causethe epidemic to spread to other areas in the city in a short time. It has been determined thatpublic transportation, which has become an “epidemic centre” in cities, is used mainly by lowincome groups during the pandemic. Thus, the fact that the epidemic is more prevalent oncertain groups results in certain parts of the city to become more vulnerable. Cities areexpected to adapt to such hazards and risks and manage the pandemic process efficiently tobuild resilience.From this point of view, in this study the role of transportation vehicles on epidemicdiseases is examined. Moreover, the impacts of particular activities or actions on the urbanresilience and the approaches to increase the urban resilience are also discussed.