Correlation of preoperative sonographic staging and postoperative histopathologic staging in patients with invasive breast cancer
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
Purpose: To assess the accuracy of preoperative sonographic staging in patients with primary invasive breast cancer. Methods: We retrospectively analyzed a prospectively kept service database of patients with newly diagnosed, unifocal, cT1-3, invasive breast cancer. All patients were diagnosed at a single center institution between January 2013 and December 2021. Clinical T stage was assessed preoperatively by ultrasound and correlated with the definite postoperative pathologic T stage. Demographics, clinical and pathological characteristics were collected. Factors influencing accuracy, over- and underdiagnosis of sonographic staging were analyzed with multivariable regression analysis. Results: A total of 2478 patients were included in the analysis. Median patients’ age was 65 years. 1577 patients (63.6%) had clinical T1 stage, 864 (34.9%) T2 and 37 (1.5%) T3 stage. The overall accuracy of sonography and histology was 76.5% (n = 1896), overestimation was observed in 9.1% (n = 225) of all cases, while underestimation occurred in 14.4% (n = 357) of all cases. Accuracy increased when clinical tumor stage cT was higher (OR 1.23; 95% CI 1.10–1.38, p ≤ 0.001). The highest accuracy was seen for patients with T2 stage (82.8%). The accuracy was lower in Luminal B tumors compared to Luminal A tumors (OR 0.71; 95% CI 0.59–0.87, p ≤ 0.001). We could not find any association between sonographic accuracy in HER2 positive patients, and demographic characteristics, or tumor-related factors. Conclusion: Our unicentric study showed a high accuracy of sonography in predicting T stage, especially for tumors with clinical T2 stage. Tumor stage and biological tumor factors do affect the accuracy of sonographic staging.
Details
Original language | English |
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Pages (from-to) | 2623-2630 |
Number of pages | 8 |
Journal | Archives of gynecology and obstetrics |
Volume | 310 |
Issue number | 5 |
Publication status | Published - Nov 2024 |
Peer-reviewed | Yes |
External IDs
PubMed | 39222087 |
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Keywords
Sustainable Development Goals
ASJC Scopus subject areas
Keywords
- Accuracy, Breast cancer, Breast cancer diagnostics, Breast imaging, HER2 positive, Sonography