Correlated gene expression supports synchronous activity in brain networks

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • Jonas Richiardi - , Stanford University, University of Geneva (Author)
  • Andre Altmann - , Stanford University (Author)
  • Anna Clare Milazzo - , Department of Veterans Affairs (Author)
  • Catie Chang - , National Institutes of Health (NIH) (Author)
  • M. Mallar Chakravarty - , McGill University (Author)
  • Tobias Banaschewski - , Central Institute of Mental Health (CIMH) (Author)
  • Gareth J. Barker - , King's College London (KCL) (Author)
  • Arun L.W. Bokde - , Trinity College Dublin (Author)
  • Uli Bromberg - , University of Hamburg (Author)
  • Christian Büchel - , University of Hamburg (Author)
  • Patricia Conrod - , King's College London (KCL), University of Montreal (Author)
  • Mira Fauth-Bühler - , Central Institute of Mental Health (CIMH) (Author)
  • Herta Flor - , Central Institute of Mental Health (CIMH) (Author)
  • Vincent Frouin - , French Alternative Energies and Atomic Energy Commission (CEA) (Author)
  • Jürgen Gallinat - , Charité – Universitätsmedizin Berlin (Author)
  • Hugh Garavan - , Trinity College Dublin, University of Vermont (Author)
  • Penny Gowland - , University of Nottingham (Author)
  • Andreas Heinz - , Charité – Universitätsmedizin Berlin (Author)
  • Hervé Lemaître - , INSERM - Institut national de la santé et de la recherche médicale, Université Paris Cité (Author)
  • Karl F. Mann - , Central Institute of Mental Health (CIMH) (Author)
  • Jean Luc Martinot - , INSERM - Institut national de la santé et de la recherche médicale, Université Paris Cité (Author)
  • Frauke Nees - , Central Institute of Mental Health (CIMH) (Author)
  • Tomáš Paus - , University of Toronto, University of Nottingham (Author)
  • Zdenka Pausova - , University of Toronto (Author)
  • Marcella Rietschel - , Central Institute of Mental Health (CIMH) (Author)
  • Trevor W. Robbins - , University of Cambridge (Author)
  • Michael N. Smolka - , Department of Psychiatry and Psychotherapy, Neuroimaging Center (Author)
  • Rainer Spanagel - , Central Institute of Mental Health (CIMH) (Author)
  • Andreas Ströhle - , Charité – Universitätsmedizin Berlin (Author)
  • Gunter Schumann - , King's College London (KCL) (Author)
  • Mike Hawrylycz - , Allen Institute for Brain Science (Author)
  • Jean Baptiste Poline - , University of California at Berkeley (Author)
  • Michael D. Greicius - , Stanford University (Author)

Abstract

During rest, brain activity is synchronized between different regions widely distributed throughout the brain, forming functional networks. However, the molecular mechanisms supporting functional connectivity remain undefined. We show that functional brain networks defined with resting-state functional magnetic resonance imaging can be recapitulated by using measures of correlated gene expression in a post mortem brain tissue data set. The set of 136 genes we identify is significantly enriched for ion channels. Polymorphisms in this set of genes significantly affect resting-state functional connectivity in a large sample of healthy adolescents. Expression levels of these genes are also significantly associated with axonal connectivity in the mouse. The results provide convergent, multimodal evidence that resting-state functional networks correlate with the orchestrated activity of dozens of genes linked to ion channel activity and synaptic function.

Details

Original languageEnglish
Pages (from-to)1241-1244
Number of pages4
JournalScience
Volume348
Issue number6240
Publication statusPublished - 12 Jun 2015
Peer-reviewedYes

External IDs

PubMed 26068849
ORCID /0000-0001-5398-5569/work/161890810

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