Core-Shell Structures of Oligosaccharide-Functionalized Hyperbranched Poly(ethylene imines)

Research output: Contribution to journal › Research article › Contributed › peer-review

Contributors

  • Andreas F. Thuenemann - , Federal Institute for Materials Research and Testing Berlin (Author)
  • Ralf Bienert - , Federal Institute for Materials Research and Testing Berlin (Author)
  • Dietmar Appelhans - , Leibniz Institute of Polymer Research Dresden (Author)
  • Brigitte Voit - , Chair of Organic Chemistry of Polymers, Leibniz Institute of Polymer Research Dresden (Author)

Abstract

Hyperbranched poly(ethylene imine)s (PEIs) functionalized with maltose, maltotriose, and maltoheptaose form distinct core-shell globular nanoparticles as revealed by small-angle X-ray scattering (SAXS). The solution structures are quantified using the Beaucage unified exponential/power-law approach. SAXS results were confirmed with dynamic light scattering (DLS). We found that all PEI structures are completely insensitive to changes of temperature (5 degrees C < T < 80 degrees C) and pH (1 < pH < 10). This remarkable stability of a compact spherical polymeric structure makes the modified PEIs promising for a wide range of biomedical applications.

Details

Original languageEnglish
Pages (from-to)2362-2369
Number of pages8
JournalMacromolecular chemistry and physics : MCP
Volume213
Issue number22
Publication statusPublished - 23 Nov 2012
Peer-reviewedYes

External IDs

WOS 000312654100004
Scopus 84869060984
ORCID /0000-0002-4531-691X/work/148607943

Keywords

Keywords

  • Colloids, Core-shell polymers, Nanoparticles, Polyamines, small-angle X-ray scattering (SAXS)