Coprinellus andreorum sp. nov. is described for the first time from Malta. A full description with illustrations of the macro- and micromorphological characters, as well as its phylogenetic position is provided. This species differs from Coprinellus aureogranulatus by the large pleurocystidia, the narrower spores and multidigitate caulocystidia. Some species from sect. Domestici are discussed and compared.