Continuous Wet Spinning of Regenerated Silk Fibers from Spinning Dopes Containing 4% Fibroin Protein

Research output: Contribution to journalResearch articleContributedpeer-review



The wet spinning of fibers from regenerated silk fibroin has long been a research goal. Due to the degradation of the molecular structure of the fibroin protein during the preparation of the regenerated silk fibroin solution, fibroin concentrations with at least 10% protein content are required to achieve sufficient viscosity for wet spinning. In this study, a spinning dope formulation of regenerated silk fibroin is presented that shows a rheological behavior similar to that of native silk fibroin isolated from the glands of B. mori silkworm larvae. In addition, we present a wet-spinning process that enables, for the first time, the continuous wet spinning of regenerated silk fibroin with only 4% fibroin protein content into an endless fiber. Furthermore, the tensile strength of these wet-spun regenerated silk fibroin fibers per percentage of fibroin is higher than that of all continuous spinning approaches applied to regenerated and native silk fibroin published so far.


Original languageEnglish
Article number13492
JournalInternational Journal of Molecular Sciences
Issue number17
Publication statusPublished - 30 Aug 2023

External IDs

ORCID /0000-0002-7440-9277/work/142239112
Scopus 85170222522
Mendeley 6245ea5d-1dd8-3cb4-8d36-e66edc56b9f2
WOS 001064171900001
PubMed 37686298



  • Bombyx mori, Silk fibroin, Tensile properties, Wet spinning, silk fibroin, tensile properties, wet spinning, Fibroins, Rheology, Bombyx, Silk, Animals, Larva