Continuous monitoring of molecular biomarkers in microfluidic devices

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • Andrea Idili - , University of California at Santa Barbara, University of Rome Tor Vergata (Author)
  • Helena Montón - , University of California at Santa Barbara (Author)
  • Mariana Medina-Sánchez - , Leibniz Institute for Solid State and Materials Research Dresden (Author)
  • Bergoi Ibarlucea - , Center for Advancing Electronics Dresden (cfaed), Max Bergmann Center of Biomaterials Dresden (Author)
  • Gianaurelio Cuniberti - , Chair of Materials Science and Nanotechnology (Author)
  • Oliver G. Schmidt - , Leibniz Institute for Solid State and Materials Research Dresden, Architectures and Integration of Nanomembranes (MAIN), TUD Dresden University of Technology (Author)
  • Kevin W. Plaxco - , University of California at Santa Barbara (Author)
  • Claudio Parolo - , University of California at Santa Barbara, Barcelona Institute for Global Health (ISGlobal) Hospital Clínic (Author)

Abstract

The ability to monitor molecular targets is crucial in fields ranging from healthcare to industrial processing to environmental protection. Devices employing biomolecules to achieve this goal are called biosensors. Over the last half century researchers have developed dozens of different biosensor approaches. In this chapter we analyze recent advances in the biosensing field aiming at adapting these to the problem of continuous molecular monitoring in complex sample streams, and how the merging of these sensors with lab-on-a-chip technologies would be beneficial to both. To do so we discuss (1) the components that comprise a biosensor, (2) the challenges associated with continuous molecular monitoring in complex sample streams, (3) how different sensing strategies deal with (or fail to deal with) these challenges, and (4) the implementation of these technologies into lab-on-a-chip architectures.

Details

Original languageEnglish
Pages (from-to)295-333
Number of pages39
JournalProgress in Molecular Biology and Translational Science
Volume187
Issue number1
Publication statusPublished - Jan 2022
Peer-reviewedYes

External IDs

PubMed 35094779
ORCID /0000-0002-9899-1409/work/142249204

Keywords

Keywords

  • Analytical devices, Biosensors, Continuous sensing, Diagnostics, Real-time sensing, Humans, Biosensing Techniques, Biomarkers, Lab-On-A-Chip Devices

Library keywords