Continuous enantioselective crystallization of chiral compounds in coupled fluidized beds
Research output: Contribution to journal › Review article › Contributed › peer-review
Contributors
Abstract
This review summarizes results of an interdisciplinary project devoted to improve the access to enantiopure components by applying an advanced continuous separation process exploiting the principle of kinetically controlled preferential crystallization within two coupled fluidized beds located in conically shaped tubular crystallizers. The process efficiently combines selective crystallization with integrated product classification. Along with summarizing the related literature, new original results are presented with respect to theoretical process description and experimental validation. Although only one chiral system is considered specifically, namely the separation of the enantiomers of a racemic mixture of asparagine monohydrate using water as solvent, general conclusions will be drawn to highlight the large potential of the process principle. The conceptual approaches presented are seen as useful tools for the development of productive continuously operating enantioselective crystallization processes. They are applicable to separate enantiomers of numerous chiral molecules.
Details
Original language | English |
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Article number | 129627 |
Journal | Chemical engineering journal |
Volume | 422 |
Publication status | Published - 15 Oct 2021 |
Peer-reviewed | Yes |
Keywords
ASJC Scopus subject areas
Keywords
- Asparagine monohydrate, CFD-DEM simulation, Chiral separation, Continuous preferential crystallization, Fluidized beds, Population balance model