Conserved physical mechanisms of cell and tissue elongation

Research output: Contribution to journalReview articleContributedpeer-review

Contributors

Abstract

Living organisms have the ability to self-shape into complex structures appropriate for their function. The genetic and molecular mechanisms that enable cells to do this have been extensively studied in several model and non-model organisms. In contrast, the physical mechanisms that shape cells and tissues have only recently started to emerge, in part thanks to new quantitative in vivo measurements of the physical quantities guiding morphogenesis. These data, combined with indirect inferences of physical characteristics, are starting to reveal similarities in the physical mechanisms underlying morphogenesis across different organisms. Here, we review how physics contributes to shape cells and tissues in a simple, yet ubiquitous, morphogenetic transformation: elongation. Drawing from observed similarities across species, we propose the existence of conserved physical mechanisms of morphogenesis.

Details

Original languageEnglish
Article numberdev202687
JournalDevelopment (Cambridge)
Volume151
Issue number10
Publication statusPublished - May 2024
Peer-reviewedYes

External IDs

PubMed 38767601

Keywords

Keywords

  • Conserved mechanisms, Elongation, Growth, Mechanics, Mechanobiology, Morphogenesis, Animals, Models, Biological, Humans, Cell Shape