Numerical simulation of complex fracture patterns and fragmentation in tempered glass remains a challenging task, requiring robust and reliable fracture models. This contribution presents a newly developed computational framework for fracture and undertakes its validation, considering the phenomenon of tempered glass fragmentation. A qualitative validation of the model is presented, where the simulations are shown to successfully reproduce key features of tempered glass fracture that are documented in the literature, including crack branching, crack merging, crack arrest, and the formation of secondary cracks. The mesh sensitivity of the numerical framework for simulating tempered glass fracture is investigated. Thereafter, the physical fidelity of the model is evaluated based on the predicted fragment number and mean perimeter for tempered glass samples of nominally identical geometry, under varying pre-stress levels. Moreover, the predictive performance of the computational framework is studied by simulating the fragmentation in glass specimens of different geometries and pre-stress levels, using unchanged material parameters. The numerical results of the fracture model are compared with both experimental data obtained by the authors and results reported in the literature. The simulation outcomes show good agreement with experimental counterparts in terms of the number and mean perimeter of glass fragments, confirming the reliability and predictive capability of the proposed framework.