Comparative analysis of intraoperative thermal and optical imaging for identification of the human primary sensory cortex

Research output: Contribution to journalResearch articleContributedpeer-review

Abstract

SIGNIFICANCE: The precise identification and preservation of functional brain areas during neurosurgery are crucial for optimizing surgical outcomes and minimizing postoperative deficits. Intraoperative imaging plays a vital role in this context, offering insights that guide surgeons in protecting critical cortical regions.

AIM: We aim to evaluate and compare the efficacy of intraoperative thermal imaging (ITI) and intraoperative optical imaging (IOI) in detecting the primary somatosensory cortex, providing a detailed assessment of their potential integration into surgical practice.

APPROACH: Data from nine patients undergoing tumor resection in the region of the somatosensory cortex were analyzed. Both IOI and ITI were employed simultaneously, with a specific focus on the areas identified as the primary somatosensory cortex (S1 region). The methodologies included a combination of imaging techniques during distinct phases of rest and stimulation, confirmed by electrophysiological monitoring of somatosensory evoked potentials to verify the functional areas identified by both imaging methods. The data were analyzed using a Fourier-based analytical framework to distinguish physiological signals from background noise.

RESULTS: Both ITI and IOI successfully generated reliable activity maps following median nerve stimulation. IOI showed greater consistency across various clinical scenarios, including those involving cortical tumors. Quantitative analysis revealed that IOI could more effectively differentiate genuine neuronal activity from artifacts compared with ITI, which was occasionally prone to false positives in the presence of cortical abnormalities.

CONCLUSIONS: ITI and IOI produce comparable functional maps with moderate agreement in Cohen's kappa values. Their distinct physiological mechanisms suggest complementary use in specific clinical scenarios, such as cortical tumors or impaired neurovascular coupling. IOI excels in spatial resolution and mapping reliability, whereas ITI provides additional insights into metabolic changes and tissue properties, especially in pathological areas. Combined, these modalities could enhance the understanding and analysis of functional and pathological processes in complex neurosurgical cases.

Details

Original languageEnglish
Article number016002
Number of pages15
JournalJournal of biomedical optics
Volume30
Issue number1
Publication statusPublished - 16 Jan 2025
Peer-reviewedYes

External IDs

PubMedCentral PMC11737595
ORCID /0000-0003-0554-2178/work/176862698
ORCID /0000-0002-3776-3453/work/176862731
ORCID /0000-0002-7267-7016/work/176863148
ORCID /0000-0002-7625-343X/work/176863201
Scopus 85216065605

Keywords

Keywords

  • Adult, Aged, Brain Mapping/methods, Brain Neoplasms/surgery, Evoked Potentials, Somatosensory/physiology, Female, Humans, Male, Middle Aged, Monitoring, Intraoperative/methods, Optical Imaging/methods, Somatosensory Cortex/diagnostic imaging, Thermography/methods