Colorimetric Biosensors Based on Polymer/Gold Hybrid Nanoparticles: Topological Effects of the Polymer Coating

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • Ruosong Wang - , Leibniz Institute of Polymer Research Dresden (Author)
  • Lucas Schirmer - , Leibniz Institute of Polymer Research Dresden (Author)
  • Torsten Wieduwilt - , Leibniz Institute of Photonic Technology (Author)
  • Ronny Förster - , Leibniz Institute of Photonic Technology (Author)
  • Markus A. Schmidt - , Leibniz Institute of Photonic Technology, Friedrich Schiller University Jena (Author)
  • Uwe Freudenberg - , Leibniz Institute of Polymer Research Dresden (Author)
  • Carsten Werner - , Center for Regenerative Therapies Dresden, Chair of Biofunctional Polymer Materials, Leibniz Institute of Polymer Research Dresden (Author)
  • Andreas Fery - , Chair of Physical Chemistry of Polymeric Materials, Leibniz Institute of Polymer Research Dresden (Author)
  • Christian Rossner - , Leibniz Institute of Polymer Research Dresden, TUD Dresden University of Technology (Author)

Abstract

Gold nanoparticles decorated with analyte recognition units can form the basis of colorimetric (bio)sensors. The presentation of those recognition units may play a critical role in determining sensor sensitivity. Herein, we use a model system to investigate the effect of the architecture of a polymeric linker that connects gold nanoparticles with the recognition units. Our results show that the number of the latter that can be adsorbed during the assembly of the colorimetric sensors depends on the linker topology. We also show that this may lead to substantial differences in colorimetric sensor performance, particularly in situations in which the interactions with the analyte are comparably weak. Finally, we discuss design principles for efficient colorimetric sensor materials based on our findings.

Details

Original languageEnglish
Pages (from-to)12325-12332
Number of pages8
JournalLangmuir
Volume38
Issue number40
Publication statusPublished - 11 Oct 2022
Peer-reviewedYes

External IDs

PubMed 36154138
ORCID /0000-0003-0189-3448/work/159607196