Coilin levels modulate cell cycle progression and γh2AX levels in etoposide treated U2OS cells
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
Coilin is considered the Cajal body (CB) marker protein. In this report, we investigated the role of coilin in the DNA damage response and found that coilin reduction correlated with significantly increased levels of soluble γH2AX in etoposide treated U2OS cells. Additionally, coilin levels influenced the proliferation rate and cell cycle distribution of cells exposed to etoposide. Moreover, coilin overexpression inhibited nucleolar localization of endogenous coilin in etoposide treated U2OS cells. Collectively, these data provide additional evidence for coilin and CBs in the DNA damage response.
Details
Original language | English |
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Pages (from-to) | 3404-3409 |
Number of pages | 6 |
Journal | FEBS letters |
Volume | 586 |
Issue number | 19 |
Publication status | Published - 21 Sept 2012 |
Peer-reviewed | Yes |
Externally published | Yes |
External IDs
PubMed | 22986342 |
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ORCID | /0000-0001-8501-1566/work/173989188 |
Keywords
ASJC Scopus subject areas
Keywords
- γH2AX, Cell cycle, Coilin, DNA damage