Cohesin in oocytes-tough enough for Mammalian meiosis?

Research output: Contribution to journalResearch articleContributedpeer-review


  • Ekaterina Revenkova - , Icahn School of Medicine at Mount Sinai (Author)
  • Caroline Adelfalk - (Author)
  • Rolf Jessberger - , Institute of Physiological Chemistry, Medical Faculty Carl Gustav Carus (Author)


Sister chromatid cohesion is essential for cell division. During meiosis, it is also required for proper synapsis of pairs of sister chromatids and for chiasma formation and maintenance. Since mammalian oocytes remain arrested in late prophase for a very long period-up to five decades in humans-the preservation of cohesion throughout this period is a formidable challenge. Mouse models with cohesin deficiencies and aging wild-type mice showed that this challenge is not fully met: cohesion weakens and deteriorates with increasing age. These recent findings have highly significant implications for our comprehension of the genesis of aneuploidies.


Original languageEnglish
Pages (from-to)495-504
Number of pages10
Issue number3
Publication statusPublished - 13 Dec 2010

External IDs

PubMedCentral PMC3966221
Scopus 79952094202