Cohesin in determining chromosome architecture

Research output: Contribution to journalReview articleContributedpeer-review

Contributors

Abstract

Cells use ring-like structured protein complexes for various tasks in DNA dynamics. The tripartite cohesin ring is particularly suited to determine chromosome architecture, for it is large and dynamic, may acquire different forms, and is involved in several distinct nuclear processes. This review focuses on cohesin's role in structuring chromosomes during mitotic and meiotic cell divisions and during interphase.

Details

Original languageEnglish
Pages (from-to)1386-1393
Number of pages8
JournalExperimental Cell Research
Volume318
Issue number12
Publication statusPublished - 15 Jul 2012
Peer-reviewedYes

External IDs

Scopus 84861949299
PubMed 22472347

Keywords

Keywords

  • Animals, Cell Cycle Proteins/genetics, Cell Nucleus/genetics, Chromosomal Proteins, Non-Histone/genetics, Chromosomes/chemistry, Humans, Interphase/genetics, Meiosis/genetics, Mitosis/genetics, Models, Biological, Nucleic Acid Conformation, Sister Chromatid Exchange/genetics