Clonal Analysis Delineates Transcriptional Programs of Osteogenic and Adipogenic Lineages of Adult Mouse Skeletal Progenitors

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Contributors

Abstract

In this article, Rostovskaya and colleagues established clonal skeletal progenitors with distinct differentiation properties from mouse bone marrow. RNA-seq analysis revealed transcriptional signatures of osteogenic and adipogenic lineages and IFNγ signaling as potential regulator of cell fate commitment. IFNγ is a negative regulator of Egr1 and Egr2 transcription factors. Egr1 maintains adipogenic and Egr2 suppresses osteogenic transcriptional program and commitment.

Details

Original languageEnglish
Pages (from-to)212-227
Number of pages16
JournalStem cell reports
Volume11
Issue number1
Publication statusPublished - 10 Jul 2018
Peer-reviewedYes

External IDs

PubMed 29937146

Keywords

ASJC Scopus subject areas

Keywords

  • bone marrow stromal cells, Egr1/2 transcription factors, interferon-γ signaling, lineage commitment, skeletal progenitors, transcriptional signatures

Library keywords