Cidofovir and foscarnet for treatment of human herpesvirus 6 encephalitis in a neutropenic stem cell transplant recipient.

Research output: Contribution to journal › Research article › Contributed › peer-review

Contributors

  • Christoph Pöhlmann - , Institute of Medical Microbiology and Virology (Author)
  • Johannes Schetelig - , Department of internal Medicine I, University Hospital Carl Gustav Carus Dresden (Author)
  • Ulrike Reuner - , Department of Neurology, University Hospital Carl Gustav Carus Dresden (Author)
  • Martin Bornhäuser - , Department of internal Medicine I, University Hospital Carl Gustav Carus Dresden (Author)
  • Thomas Illmer - , Department of internal Medicine I (Author)
  • Alexander Kiani - , Department of internal Medicine I (Author)
  • Gerhard Ehninger - , Department of internal Medicine I (Author)
  • Enno Jacobs - , Institute of Medical Microbiology and Virology (Author)
  • Jacques Rohayem - , Institute of Medical Microbiology and Virology (Author)

Abstract

We report a stem cell transplant recipient who developed human herpesvirus 6 encephalitis. Human herpesvirus 6 load indicated massive intrathecal viral replication. Administration of cidofovir followed by foscarnet was associated with total clearance of human herpesvirus 6 infection. Cidofovir and foscarnet combination therapy may be beneficial for reducing mortality of (neutropenic) stem cell transplant recipients with human herpesvirus 6 encephalitis.

Details

Original languageEnglish
Pages (from-to)e118-120
JournalClinical infectious diseases : an official publication of the Infectious Diseases Society of America
Volume44
Issue number12
Publication statusPublished - 15 Jun 2007
Peer-reviewedYes

External IDs

PubMed 17516391

Keywords

Sustainable Development Goals

ASJC Scopus subject areas