Chronic Electrical Nerve Stimulation as a Therapeutic Intervention for Peripheral Nerve Repair
Research output: Contribution to journal › Review article › Contributed › peer-review
Contributors
Abstract
When a peripheral nerve is injured after either trauma or a neurodegenerative disease, motor function and sensory perception are impaired. Repair strategies aim both at reconstructing the damaged nerve and in promoting regeneration to enhance target reinnervation and functional recovery. Advanced surgical procedures can enable efficient repair, but restoration of function remains challenging. Among various factors influencing nerve regeneration, electrical stimulation is often cited as a potential therapeutic approach to nerve repair, engaging regenerative transcriptional programs. In this report, we review both reported effects on axonal growth and functional outcomes of electrical stimulation on peripheral nerve repair and the techniques for chronic nerve stimulation, highlighting the challenges and opportunities of such repair strategies.
Details
Original language | English |
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Pages (from-to) | 43-48 |
Number of pages | 6 |
Journal | Bioelectronic Medicine |
Volume | 2 |
Issue number | 1 |
Publication status | Published - Jun 2015 |
Peer-reviewed | Yes |
Externally published | Yes |
Keywords
ASJC Scopus subject areas
Keywords
- Chronic Nerve Stimulation, Cuff Electrode, Peripheral Nerve Repair, Sciatic Function Index, Tripolar Configuration