Chromosome dynamics: the SMC protein family

Research output: Contribution to journalReview articleContributedpeer-review



Recent evidence suggests that members of the structural maintenance of chromosomes (SMC) protein family are involved in a much broader spectrum of chromosome and DNA metabolic reactions than was originally thought. Other than their role in chromosome condensation, SMC proteins are essential for sister chromatid cohesion and gene dosage compensation, and are involved in DNA recombination. This diversity of function is achieved both through the formation of different heterodimers and through their participation in higher-order protein complexes adapted to achieve specific ends.


Original languageEnglish
Pages (from-to)254-9
Number of pages6
JournalCurrent opinion in genetics & development : reviews of all advances ; evaluation of key references ; comprehensive listing of papers
Issue number2
Publication statusPublished - Apr 1998

External IDs

Scopus 0032055420



  • Animals, Carrier Proteins/metabolism, Cell Cycle Proteins, Chromatin, DNA Repair, Mitosis, Nuclear Proteins/metabolism, Recombination, Genetic, Saccharomyces cerevisiae Proteins