Cholesterol modulates glycolipid conformation and receptor activity
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
We document a new dimension of surface recognition in which communication is controlled through the collective behavior of lipids. Membrane cholesterol induces a tilt in glycolipid receptor headgroup, resulting in loss of access for ligand binding. This property appears to organize erythrocyte blood group presentation and glycolipid receptor function during the activation of sperm fertility, suggesting that lipid 'allostery' is a means to regulate membrane recognition processes.
Details
Original language | English |
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Pages (from-to) | 260-262 |
Number of pages | 3 |
Journal | Nature chemical biology |
Volume | 7 |
Issue number | 5 |
Publication status | Published - May 2011 |
Peer-reviewed | Yes |
Externally published | Yes |
External IDs
WOS | 000289617800008 |
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Scopus | 79955062451 |
ORCID | /0000-0003-2083-0506/work/148607254 |