Chlorpromazine combined with cidofovir for treatment of a patient suffering from progressive multifocal leukoencephalopathy

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • Christoph Pöhlmann - , University Hospital Carl Gustav Carus Dresden, Institute of Medical Microbiology and Virology (Author)
  • Kristina Hochauf - , Institute of Medical Microbiology and Virology (Author)
  • Christoph Röllig - , Department of Internal Medicine I, University Hospital Carl Gustav Carus Dresden (Author)
  • Johannes Schetelig - , Department of Internal Medicine I, University Hospital Carl Gustav Carus Dresden (Author)
  • Olaf Wunderlich - , University Hospital Carl Gustav Carus Dresden, Institute and Polyclinic of Diagnostic and Interventional Radiology (Author)
  • Dirk Bandt - , University Hospital Carl Gustav Carus Dresden, Institute of Medical Microbiology and Virology (Author)
  • Gerhard Ehninger - , University Hospital Carl Gustav Carus Dresden, Department of internal Medicine I (Author)
  • Enno Jacobs - , University Hospital Carl Gustav Carus Dresden, Institute of Medical Microbiology and Virology (Author)
  • Jacques Rohayem - , University Hospital Carl Gustav Carus Dresden, Institute of Medical Microbiology and Virology (Author)

Abstract

We report on a stem cell-transplanted patient with B cell chronic lymphatic leukemia who presented with a subacute onset of focal neurological deficits, gait abnormalities, emotional lability and dementia. Progressive multifocal leukoencephalopathy was diagnosed by magnetic resonance imaging (MRI) of the brain and detection of JC virus genome in the cerebrospinal fluid. Cidofovir and the 5HT2A receptor antagonist chlorpromazine were subsequently administered. A follow-up MRI of the brain 2 weeks after initiation of the antiviral therapy displayed progress of the demyelination, and the patient died 3 months after onset of the neurological symptoms. This report highlights the need for the development of novel and potent strategies for treatment of progressive multifocal leukoencephalopathy.

Details

Original languageEnglish
Pages (from-to)412-417
Number of pages6
Journal Intervirology : international journal of fundamental and medical virology
Volume50
Issue number6
Publication statusPublished - Feb 2008
Peer-reviewedYes

External IDs

Scopus 39749191853
PubMed 18182774

Keywords

Sustainable Development Goals

ASJC Scopus subject areas

Keywords

  • Chlorpromazine, Cidofovir, JC viral load, Progressive multifocal leukoencephalopathy