Charting the unknown currents of cellular flows and forces
Research output: Contribution to journal › Review article › Invited › peer-review
Contributors
Abstract
One of the central questions in developmental biology concerns how cells become organized into tissues of the correct size, shape and polarity. This organization depends on the implementation of a cell's genetic information to give rise to specific and coordinated cell behaviors, including cell division and cell shape change. The execution of these cell behaviors requires the active generation of mechanical forces. However, understanding how force generation is controlled and, importantly, coordinated among many cells in a tissue was little explored until the early 2000s. Suzanne Eaton was one of the pioneers in this emerging field of developmental tissue mechanics. As we briefly review here, she connected the quantitative analysis of cell behaviors with genetic assays, and integrated physical modeling with measurements of mechanical forces to reveal fundamental insights into epithelial morphogenesis at cell- and tissue-level scales.
Details
Original language | English |
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Journal | Development (Cambridge) |
Volume | 147 |
Issue number | 24 |
Publication status | Published - 21 Dec 2020 |
Peer-reviewed | Yes |
External IDs
Scopus | 85099076123 |
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Keywords
Subject groups, research areas, subject areas according to Destatis
Keywords
- Drosophila, E-cadherin, Cell packing geometry, Junctional remodeling, Tissue mechanics, Drosophila, E-cadherin, Cell packing geometry, Junctional remodeling, Tissue mechanics