Characterization of the osseointegration of Algipore and Algipore modified with mineralized collagen type i

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • Matthias C. Schulz - , Department of Oral and Maxillofacial Surgery, Centre for translational bone, joint and soft tissue research (Author)
  • Anja Lode - , Centre for Translational Bone, Joint and Soft Tissue Research (Author)
  • Sabine Wittig - , Department of Oral and Maxillofacial Surgery (Author)
  • Bernd Stadlinger - , Department of Oral and Maxillofacial Surgery, Centre for translational bone, joint and soft tissue research (Author)
  • Eberhard Kuhlisch - , Institute for Medical Informatics and Biometry (Author)
  • Uwe Eckelt - , Department of Oral and Maxillofacial Surgery, Centre for translational bone, joint and soft tissue research (Author)
  • Michael Gelinsky - , Centre for Translational Bone, Joint and Soft Tissue Research (Author)
  • Ronald Mai - , Department of Oral and Maxillofacial Surgery, Centre for translational bone, joint and soft tissue research (Author)

Abstract

Objective: Algipore is a clinically established bone substitute. The present study evaluated the osseoconductive and resorptive characteristics of Algipore modified with collagen type I (ACI). Study Design: Three defects of 10 × 3 mm were set in the frontal bone of 10 adult female minipigs. One cavity was filled with commercially available Algipore, and the second with ACI. The third cavity was left unfilled and served as reference. After 4 months of healing, the animals were humanely killed. Bone formation and resorption characteristics of the substitutes were evaluated histomorphologically and histomorphometrically using Donath's sawing and grinding technique. Results: Neither material caused inflammatory reactions. Compared with controls, both substitutes showed significantly higher fractions of trabecular bone (control: 42.2%; Algipore: 58.7%, [P <.001]; ACI: 53.6%, [P =.013]). After 4 months, the remaining fraction of Algipore was 42.2% and the fraction of ACI was 47.9% (P =.016). Conclusions: The present study demonstrates that the modification of Algipore with collagen I does not show any benefits compared with pure Algipore in small calvarial bone defects in minipigs.

Details

Original languageEnglish
Pages (from-to)S160-S166
JournalOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Volume114
Issue numberSuppl 5
Publication statusPublished - Nov 2012
Peer-reviewedYes

External IDs

PubMed 23063393
ORCID /0000-0001-9075-5121/work/167217382