Flow boiling occurs when a subcooled liquid enters a heating pipe and its temperature near the heating wall exceeds the boiling onset temperature. Bubbles are generated on the heating wall and the more downstream the larger the average bubble size due to progressing evaporation and coalescence. Further downstream, the two-phase flow morphologies may change from bubbly to slug, plug, and annular flow. Since these flow patterns have a great impact on the heat and mass transfer rates, an accurate prediction of them becomes critical. In this work, the recently developed GENeralized-TwO Phase concept (GENTOP) was used for flow patterns transition modelling and their effects on the wall heat transfer during the upward subcooled flow boiling inside a vertical heating pipe. Furthermore, a previously developed mechanistic bubble dynamics model was implemented in the GENTOP framework as a sub-model. This model is based on the force balance on a single growing bubble considering evaporation of the microlayer underneath the bubble, thermal diffusion and condensation around the bubble as well as the dynamic inclination and contact angles. It does not require a recalibration of parameters to predict the bubble dynamics. For implementing this model in the Euler-Euler (E-E) framework an extension of the current nucleation site density and heat partitioning model was required. Eventually, for a generic test case, flow boiling regimes of water in a vertical heating pipe were simulated using ANSYS CFX 18.2.