In the present study, we assessed the capabilities of Eulerian-Eulerian CFD two-phase flow simulation with the homogeneous Multiple Size Group Model (MUSIG) and consideration of breakup and coalescence under three-dimensional flow conditions. We compared void fraction, bubble size and bubble velocity distributions against experimental data from vertical gas-disperse two-phase flow in a pipe with a flow obstruction. The simulation results generally agree well upstream the obstacle, where we have a typically developed pipe flow. Downstream of the obstacle void fraction is overpredicted while bubble velocity is underpredicted. The bubble size distribution has no clear trend. With higher liquid velocities, the deviations increase. As a conclusion, the simulation has difficulties to balance the gas fraction in the strong vortex in the shadow of the obstacle. Here further model improvement is needed.