Cerebral and regional organ perfusion in pigs during xenon anaesthesia
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
Little is known about the haemodynamic effects of inhaled xenon on regional organ perfusion. The aim of this study was to investigate the effect of 79% xenon ventilation on organ perfusion in pigs. We investigated 10 pigs, which were randomly allocated to receive either xenon 79% or total intravenous anaesthesia (TIVA)/oxygen anaesthesia. Microspheres were used to determine organ perfusion. The following regions of interest were investigated: Cerebral cortex, medulla oblongata, brainstem, cerebellum, liver, kidney, small intestine, colon, muscle, skin and heart. The results demonstrated a significant increase in regional perfusion in the brainstem (+63%), cerebral cortex (+38%), medulla oblongata (+35%) and cerebellum (+34%). All other organs showed no significant change in regional perfusion. We conclude that xenon should be used with caution in clinical situations associated with pathological increases in intracranial pressure, e.g. neurosurgical procedures, head injury, cerebral mass lesions or stroke.
Details
Original language | English |
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Pages (from-to) | 1154-1159 |
Number of pages | 6 |
Journal | Anaesthesia |
Volume | 56 |
Issue number | 12 |
Publication status | Published - 2001 |
Peer-reviewed | Yes |
Externally published | Yes |
External IDs
PubMed | 11736770 |
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Keywords
ASJC Scopus subject areas
Keywords
- Anaesthesia: veterinary, Anaesthetics, gases: xenon