CD-CODE 2.0: an enhanced condensate knowledgebase integrating pathobiology, condensate modulating drugs, and host–pathogen interactions

Research output: Contribution to journal › Research article › Contributed › peer-review

Contributors

  • Ksenia Kuznetsova - , Max Planck Institute of Molecular Cell Biology and Genetics, Center for Systems Biology Dresden (CSBD) (Author)
  • Maxim Scheremetjew - , Max Planck Institute of Molecular Cell Biology and Genetics, Center for Systems Biology Dresden (CSBD) (Author)
  • Jialin Yin - , Max Planck Institute of Molecular Cell Biology and Genetics, Center for Systems Biology Dresden (CSBD) (Author)
  • Hong Kee Moon - , Max Planck Institute of Molecular Cell Biology and Genetics, Center for Systems Biology Dresden (CSBD) (Author)
  • Diego A. Vargas - , Dewpoint Therapeutics GmbH (Author)
  • Anna Hadarovich - , Max Planck Institute of Molecular Cell Biology and Genetics, Center for Systems Biology Dresden (CSBD) (Author)
  • Natasha Lewis - , Max Planck Institute of Molecular Cell Biology and Genetics, Center for Systems Biology Dresden (CSBD) (Author)
  • Carsten Hoege - , Max Planck Institute of Molecular Cell Biology and Genetics, Center for Systems Biology Dresden (CSBD) (Author)
  • Chi Fung Willis Chow - , Max Planck Institute of Molecular Cell Biology and Genetics, Center for Systems Biology Dresden (CSBD) (Author)
  • David Kuster - , Max Planck Institute of Molecular Cell Biology and Genetics, Center for Systems Biology Dresden (CSBD) (Author)
  • Jik Nijssen - , Max Planck Institute of Molecular Cell Biology and Genetics, Center for Systems Biology Dresden (CSBD) (Author)
  • Alberto Hernandez-Armendariz - , Clusters of Excellence PoL: Physics of Life, Chair of Cell and Tissue Control (PoL), Max Planck Institute of Molecular Cell Biology and Genetics (Author)
  • Jonathan C. Savage - , Max Planck Institute of Molecular Cell Biology and Genetics, Center for Systems Biology Dresden (CSBD) (Author)
  • Yu Wei - , Max Planck Institute of Molecular Cell Biology and Genetics, Center for Systems Biology Dresden (CSBD) (Author)
  • Silja Zedlitz - , Max Planck Institute of Molecular Cell Biology and Genetics, Center for Systems Biology Dresden (CSBD), Max Planck School Matter to Life (Author)
  • Hari Raj Singh - , Max Planck Institute of Molecular Cell Biology and Genetics, Center for Systems Biology Dresden (CSBD) (Author)
  • Soumyadeep Ghosh - , Max Planck Institute of Molecular Cell Biology and Genetics, Center for Systems Biology Dresden (CSBD) (Author)
  • Allysa P. Kemraj - , SUNY Upstate Medical University, Dewpoint Therapeutics, Inc. (Author)
  • Lena Hersemann - , Max Planck Institute of Molecular Cell Biology and Genetics, Center for Systems Biology Dresden (CSBD) (Author)
  • Anthony A. Hyman - , Max Planck Institute of Molecular Cell Biology and Genetics, Center for Systems Biology Dresden (CSBD), Clusters of Excellence PoL: Physics of Life (Author)
  • Diana M. Mitrea - , Dewpoint Therapeutics, Inc. (Author)
  • Agnes Toth-Petroczy - , Max Planck Institute of Molecular Cell Biology and Genetics, Center for Systems Biology Dresden (CSBD), Clusters of Excellence PoL: Physics of Life (Author)

Abstract

CD-CODE 2.0 (https://cd-code.org) is an enhanced web application and database of condensates, expanding the utility of version 1.0 for biomedical research. New features include data on nucleic acids condensate components, infectious condensates, condensate modulating drugs, and disease-linked condensates. Enhanced search functions, programmatic access, and relational architecture enable interconnectivity across major biomedical databases (e.g. condensates, proteins, chemistry, and disease), fostering systems-level insights and accelerating hypothesis generation and therapeutic discovery through the lens of condensate biology.

Details

Original languageEnglish
Pages (from-to)D375-D382
JournalNucleic acids research
Volume54
Issue number1
Publication statusPublished - 6 Jan 2026
Peer-reviewedYes

External IDs

PubMed 41207295

Keywords

ASJC Scopus subject areas