Catching new targets in metabolic disease with a zebrafish

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

Abstract

Traditionally, the development of novel therapeutics for metabolic diseases has relied mainly on high-throughput screening using biochemical or cell-based assays. While this approach represents a driving force in drug discovery, there is also a need to perform large-scale screens without disrupting inter-organ communication and tissue architecture, essential components for understanding the complexity of metabolic regulation and the identification of small molecules with appropriate biological activities in vivo. Hence, the zebrafish Danio rerio is gaining popularity in metabolic research and drug discovery, as this animal model allows screening of small molecules in the context of the whole-organism. Moreover, the zebrafish exhibits conserved function of the pancreas, liver and adipose tissue, which can be leveraged to identify novel targets in metabolic regulation, as well as to study the role of conserved genes associated with the risk of metabolic diseases in humans. Here we highlight recent advances in the identification of targets in metabolic regulation using the zebrafish as a model.

Details

Original languageEnglish
Pages (from-to)41-50
Number of pages10
JournalCurrent opinion in pharmacology
Volume37
Publication statusPublished - Dec 2017
Peer-reviewedYes

External IDs

PubMed 28888214
Scopus 85028707862

Keywords

Keywords

  • Beta-cell mass, Body-fat distribution, Genetic screen, Adipose-tissue, Liver-disease, Glucose-homeostasis, Danio-rerio, In-vivo, Regeneration, Pancreas

Library keywords