Cardiomyocyte renewal in the human heart: Insights fromthe fall-out

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • Eniko Lázár - , Karolinska Institutet (Author)
  • Hesham A. Sadek - , University of Texas Southwestern Medical Center (Author)
  • Olaf Bergmann - , Technische Universität Dresden, Karolinska Institutet (Author)

Abstract

The capacity of the mammalian heart to regenerate cardiomyocytes has been debated over the last decades. However, limitations in existing techniques to track and identify nascent cardiomyocytes have often led to inconsistent results. Radiocarbon (14C) birth dating, in combination with other quantitative strategies, allows to establish the number and age of human cardiomyocytes, making it possible to describe their age distribution and turnover dynamics. Accurate estimates of cardiomyocyte generation in the adult heart can provide the foundation for novel regenerative strategies that aim to stimulate cardiomyocyte renewal in various cardiac pathologies.

Details

Original languageEnglish
Pages (from-to)2333-2339
Number of pages7
JournalEuropean heart journal
Volume38
Issue number30
Publication statusPublished - 7 Aug 2017
Peer-reviewedYes

External IDs

PubMed 28810672
ORCID /0000-0003-1065-4107/work/141543987

Keywords

Keywords

  • Cardiomyocyte proliferation, Dynamics of renewal, Retrospective radiocarbon dating

Library keywords