Cardiac regeneration in vivo: MENDING the heart from within?

Research output: Contribution to journalReview articleContributedpeer-review


  • Olaf Bergmann - , Karolinska Institutet (Author)
  • Stefan Jovinge - , Spectrum Health, Van Andel Research Institute, Lund University (Author)


A growing body of evidence has shown that the heart is not terminally differentiated but continues to renew its cardiomyocytes even after the neonatal period. This new view of the heart increases hope for changing the strategy for treating cardiac injuries toward regenerative approaches. However, the magnitude and clinical significance of this process in homeostasis and disease and the underlying cellular and molecular mechanisms have been heavily debated. Numerous candidates for so-called cardiac stem cells (CSCs) have been proposed, but the different characteristics of these candidates make it difficult to identify the inherent source of regeneration. In this review, we revisit the field of cardiac stem cells and endogenous regeneration to elaborate how these fields may contribute to future regenerative strategies.


Original languageEnglish
Pages (from-to)523-531
Number of pages9
JournalStem cell research
Issue number3
Publication statusPublished - 1 Nov 2014
Externally publishedYes

External IDs

PubMed 25108891


ASJC Scopus subject areas