Cardiac cell therapies for the treatment of acute myocardial infarction in mice: systematic review and meta-analysis

Research output: Contribution to journalResearch articleContributedpeer-review



Backgound Aims: This meta-analysis aims at summarizing the whole body of research on cell therapies for acute myocardial infarction (MI) in the mouse model to bring forward ongoing research in this field of regenerative medicine. Despite rather modest effects in clinical trials, pre-clinical studies continue to report beneficial effects of cardiac cell therapies for cardiac repair following acute ischemic injury. Results: The authors’ meta-analysis of data from 166 mouse studies comprising 257 experimental groups demonstrated a significant improvement in left ventricular ejection fraction of 10.21% after cell therapy compared with control animals. Subgroup analysis indicated that second-generation cell therapies such as cardiac progenitor cells and pluripotent stem cell derivatives had the highest therapeutic potential for minimizing myocardial damage post-MI. Conclusions: Whereas the vision of functional tissue replacement has been replaced by the concept of regional scar modulation in most of the investigated studies, rather basic methods for assessing cardiac function were most frequently used. Hence, future studies will highly benefit from integrating methods for assessment of regional wall properties to evolve a deeper understanding of how to modulate cardiac healing after acute MI.


Original languageEnglish
Pages (from-to)640-652
Number of pages13
Issue number6
Publication statusPublished - Jun 2023

External IDs

Scopus 85150011345
Mendeley 0190e064-4c6c-3e79-b488-de806a03a048


Research priority areas of TU Dresden

Subject groups, research areas, subject areas according to Destatis

Sustainable Development Goals


  • cardiac cell therapy, meta-analysis, mouse, myocardial infarction

Library keywords