BMP Signaling Gradient Scaling in the Zebrafish Pectoral Fin

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • Rita Mateus - , University of Geneva (Author)
  • Laurent Holtzer - , University of Geneva (Author)
  • Carole Seum - , University of Geneva (Author)
  • Zena Hadjivasiliou - , University of Geneva (Author)
  • Marine Dubois - , University of Geneva (Author)
  • Frank Jülicher - , Max-Planck-Institute for the Physics of Complex Systems (Author)
  • Marcos Gonzalez-Gaitan - , University of Geneva (Author)

Abstract

Secreted growth factors can act as morphogens that form spatial concentration gradients in developing organs, thereby controlling growth and patterning. For some morphogens, adaptation of the gradients to tissue size allows morphological patterns to remain proportioned as the organs grow. In the zebrafish pectoral fin, we found that BMP signaling forms a two-dimensional gradient. The length of the gradient scales with tissue length and its amplitude increases with fin size according to a power-law. Gradient scaling and amplitude power-laws are signatures of growth control by time derivatives of morphogenetic signaling: cell division correlates with the fold change over time of the cellular signaling levels. We show that Smoc1 regulates BMP gradient scaling and growth in the fin. Smoc1 scales the gradient by means of a feedback loop: Smoc1 is a BMP agonist and BMP signaling represses Smoc1 expression. Our work uncovers a layer of morphogen regulation during vertebrate appendage development.

Details

Original languageEnglish
Pages (from-to)4292-4302.e7
JournalCell reports
Volume30
Issue number12
Publication statusPublished - 24 Mar 2020
Peer-reviewedYes
Externally publishedYes

External IDs

PubMedCentral PMC7109522
ORCID /0000-0002-6023-3880/work/153110502
Scopus 85081993448

Keywords

Keywords

  • Animal Fins/anatomy & histology, Animals, Animals, Genetically Modified, Anisotropy, Bone Morphogenetic Proteins/metabolism, Larva/ultrastructure, Organ Size, Phenotype, Signal Transduction, Zebrafish/metabolism, Zebrafish Proteins/metabolism