Biomimetic membrane systems to study cellular organization
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
During many cellular processes such as cell division, polarization and motility, the plasma membrane does not only represent a passive physical barrier, but also provides a highly dynamic platform for the interplay between lipids, membrane binding proteins and cytoskeletal elements. Even though many regulators of these interactions are known, their mutual interdependence appears to be highly complex and difficult to study in a living cell. Over the past few years, in vitro studies on membrane-cytoskeleton interactions using biomimetic membranes turned out to be extremely helpful to get better mechanistic insight into the dynamics of these processes. In this review, we discuss some of the recent developments using in vitro assays to dissect the role of the players involved: lipids in the membrane, proteins binding to membranes and proteins binding to membrane proteins. We also summarize advantages and disadvantages of supported lipid bilayers as model membrane.
Details
Original language | English |
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Pages (from-to) | 143-151 |
Number of pages | 9 |
Journal | Journal of Structural Biology |
Volume | 168 |
Issue number | 1 |
Publication status | Published - Oct 2009 |
Peer-reviewed | Yes |
External IDs
PubMed | 19348947 |
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Keywords
ASJC Scopus subject areas
Keywords
- Actin-based motility, Bacterial cytoskeleton, Cytoskeleton, Membrane, Reaction-diffusion