Biomimetic Dehydrogenation of Non‐Conventional Lignin Monomers on Cellulose Ferulate Interfaces

Research output: Contribution to journalResearch articleContributedpeer-review



Cellulose ferulate, synthesized by Mitsunobu reaction, is shaped into thin films and also used as an aqueous dispersion to perform artificial lignin polymerization on anchor groups. This biomimetic approach is carried out in a Quartz crystal microbalance with a dissipation monitoring (QCM-D) device to enable online monitoring of the dehydrogenation, applying H2O2 and adsorbed horseradish peroxidase (HRP). The systematic use of phenylpropanoids with different oxidation states, i.e., ferulic acid, coniferyl aldehyde, coniferyl alcohol, and eugenol allowed to conclude structure-property relationships. Both the deposited material, as well as the surface roughness increased with the hydrophobicity of the monomers. Beyond surface characterizations, py-GC-MS, HSQC NMR spectroscopy and Size exclusion chromatography (SEC) measurements revealed the linkage types β-β, β-5, 5-5, and β-O-4, as well as the oligomeric character of the dehydrogenation products. All samples possessed an antibacterial activity against B. subtilis and can be used in the field of antimicrobial biomaterials.


Original languageEnglish
Article number2300556
JournalMacromolecular bioscience
Publication statusPublished - 9 Mar 2024

External IDs

Scopus 85188153398
Mendeley d834da54-a5e9-3ce8-8a56-374b5fd9f2c8



  • HSQC NMR, antibacterial activity, dehydrogenation polymers, oligomers, thin films