The capabilities of state-of-the art machine tools are significantly limited by their dynamic-mechatronic system properties. The com - bined simulation of the mechanical structure and control has been established to determine dynamic tool-path inaccuracies. While machining a work piece, the structural components of a machine tool change their position towards each other, which as a result leads to a different mechanical system. There exist different strategies to include that position dependent behavior within the coupled multi body simulation. However complex model-reduction methods for the flexible FEM substructures are necessary. Furthermore a timesynchronized parallel simulation between the simulation of the mechanical structure and the simulation of the control - typically carried out as digital block simulation - is necessary. On the other hand transient simulation approaches in the FEM environment of the overall structure are theoretically capable to represent realistic models but are by fare to complex and time-consuming to be implemented for time domain simulations including control. Based on these inadequatenesses the paper shows a new approach to consider the changing system behavior due to large movements of structural components based on holistic FEM-models. It allows an efficient integrated simulation inside the digital block simulation within the limits of a linear modal analysis.