Autonomic dysregulation in multiple sclerosis
Research output: Contribution to journal › Review article › Contributed › peer-review
Contributors
Abstract
Multiple sclerosis (MS) is a chronic, progressive central neurological disease characterized by inflammation and demyelination. In patients with MS, dysregulation of the autonomic nervous system may present with various clinical symptoms including sweating abnormalities, urinary dysfunction, orthostatic dysregulation, gastrointestinal symptoms, and sexual dysfunction. These autonomic disturbances reduce the quality of life of affected patients and constitute a clinical challenge to the physician due to variability of clinical presentation and inconsistent data on diagnosis and treatment. Early diagnosis and initiation of individualized interdisciplinary and multimodal strategies is beneficial in the management of autonomic dysfunction in MS. This review summarizes the current literatureon the most prevalent aspects of autonomic dysfunction in MS and provides reference to underlying pathophysiological mechanisms as well as means of diagnosis and treatment.
Details
Original language | English |
---|---|
Pages (from-to) | 16920-16952 |
Number of pages | 33 |
Journal | International Journal of Molecular Sciences |
Volume | 16 |
Issue number | 8 |
Publication status | Published - 24 Jul 2015 |
Peer-reviewed | Yes |
External IDs
Scopus | 84937917053 |
---|---|
PubMed | 26213927 |
Keywords
Keywords
- Autonomic, Bladder, Dysfunction, Gastrointestinal, Multiple sclerosis, Orthostatic dysregulation