Pancreas surgery is complicated and associated with substantial risks and even danger of death. The surgical removal of the whole pancreas can be necessary for some indications but results in a severe and demanding form of diabetes for both the patients and treating physician. The method of islet autotransplantation involves taking the pancreas immediately after removal to a special laboratory for processing. Using enzymatic digestion and subsequent isolation and purification processes, pancreatic islets that contain the insulin-producing cells are isolated and then returned to the patient. Thereby, insulin production can be preserved and diabetes-associated burden prevented or attenuated. This case report aims to demonstrate a potential indication for simultaneous autologous islet transplantation and the positive implications for patients.