Are Structural Changes Induced by Lithium in the HIV Brain Accompanied by Changes in Functional Connectivity?
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
Lithium therapy has been shown to affect imaging measures of brain function and microstructure in human immunodeficiency virus (HIV)-infected subjects with cognitive impairment. The aim of this proof-of-concept study was to explore whether changes in brain microstructure also entail changes in functional connectivity. Functional MRI data of seven cognitively impaired HIV infected individuals enrolled in an open-label lithium study were included in the connectivity analysis. Seven regions of interest (ROI) were defined based on previously observed lithium induced microstructural changes measured by Diffusion Tensor Imaging. Generalized partial directed coherence (gPDC), based on time-variant multivariate autoregressive models, was used to quantify the degree of connectivity between the selected ROIs. Statistical analyses using a linear mixed model showed significant differences in the average node strength between pre and post lithium therapy conditions. Specifically, we found that lithium treatment in this population induced changes suggestive of increased strength in functional connectivity. Therefore, by exploiting the information about the strength of functional interactions provided by gPDC we can quantify the connectivity changes observed in relation to a given intervention. Furthermore, in conditions where the intervention is associated with clinical changes, we suggest that this methodology could enable an interpretation of such changes in the context of disease or treatment induced modulations in functional networks.
Details
Original language | English |
---|---|
Article number | 0139118 |
Number of pages | 16 |
Journal | PloS one |
Volume | 10 |
Issue number | 10 |
Publication status | Published - 5 Oct 2015 |
Peer-reviewed | Yes |
Externally published | Yes |
External IDs
PubMed | 26436895 |
---|---|
WOS | 000362499200012 |
ORCID | /0000-0001-8264-2071/work/142254070 |
Keywords
Sustainable Development Goals
ASJC Scopus subject areas
Keywords
- PARTIAL DIRECTED COHERENCE, PATTERNS, THERAPY, MODEL