For the production of geopolymer concrete (GPC), fly-ash (FA) like waste material has been effectively utilized by various researchers. In this paper, the soft computing techniques known as gene expression programming (GEP) are executed to deliver an empirical equation to estimate the compressive strength f_c ¹ of GPC made by employing FA. To build a model, a consistent, extensive and reliable data base is compiled through a detailed review of the published research. The compiled data set is comprised of 298 f_c ¹ experimental results. The utmost dominant parameters are counted as explanatory variables, in other words, the extra water added as percent FA (%E_W), the percentage of plasticizer (%P), the initial curing temperature (T), the age of the specimen (A), the curing duration (t), the fine aggregate to total aggregate ratio (F/A_G), the percentage of total aggregate by volume (%A_G), the percent SiO2 solids to water ratio (% S/W) in sodium silicate (Na₂SiO₃) solution, the NaOH solution molarity (M), the activator or alkali to FA ratio (A_L/F_A), the sodium oxide (Na₂O) to water ratio (N/W) for preparing Na₂SiO₃ solution, and the Na₂SiO₃ to NaOH ratio (N_s/N_o). A GEP empirical equation is proposed to estimate the f_c ¹ of GPC made with FA. The accuracy, generalization, and prediction capability of the proposed model was evaluated by performing parametric analysis, applying statistical checks, and then compared with non-linear and linear regression equations.