Antibiotic Potential of the Ambigol Cyanobacterial Natural Product Class and Simplified Synthetic Analogs

Research output: Contribution to journalResearch articleContributedpeer-review



The ambigols are cyanobacterial natural products characterized by three polychlorinated aromatic building blocks connected by biaryl and biaryl ether bridges. All ambigols known to date possess promising biological activities. Most significantly, ambigol A was reported to have antibacterial activity against Gram-positive bacteria, such as Bacillus megaterium and B. subtilis. We established a diverse compound library for in-depth biological evaluation building on our previous bio- and total synthetic research on this natural product family. To explore the antimicrobial potential in detail and to determine initial structure-activity relationships of this product class, a large set of dimeric and trimeric compounds were screened against selected bacterial and Candida target strains. Our results reveal exceptional antibiotic activity of the ambigols, especially against challenging clinical isolates.


Original languageEnglish
Pages (from-to)1941–1948
Number of pages8
JournalACS Infectious Diseases
Issue number10
Publication statusPublished - 13 Oct 2023

External IDs

PubMed 37655776
WOS 001061172000001


Sustainable Development Goals

ASJC Scopus subject areas


  • ambigols, antibiotic screening, cell membrane integrity, drug-resistant Staphylococcus aureus, Ambigols, Cell membrane integrity, Antibiotic screening