Drivers of commercial vehicles are exposed to noise and vibrations during their occupation. The signal characteristics of these exposures can lead to different degrees of annoyance perception, even below the legal daily exposure limits. In addition, simultaneous exposure to sound and vibration may lead to potential interaction effects between the two stimuli, influencing the total annoyance perception. Therefore, a perception experiment was designed to ask the participants about the perceived total annoyance caused by simultaneous noise and seat vibrations in commercial vehicles, presenting modified sound and seat vibrations, recorded inside of a mini-excavator. Multimodal interaction effects of noise and vibrations were investigated by changing the intensity of both stimuli. Furthermore, the influence of low-frequency signal components of the sound signal with and without simultaneous seat vibrations was investigated by specific changes in the sound spectrum.