Analysis of the polymorphic prion protein gene codon 129 in idiopathic Parkinson's disease
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
Idiopathic Parkinson's disease (IPD) is a neurodegenerative disorder of unknown aetiology. Histopathological similarities between IPD and Creutzfeldt-Jakob prion disease (CJD) have been suggested. Homozygosity at polymorphic prion protein gene codon 129 (PRNP129) is a risk factor for developing CJD. Therefore we investigated a putative genetic link between CJD and IPD by studying PRNP129 genotype segregation in 81 patients with IPD. We did not ascertain a different PRNP129 genotype distribution in IPD patients compared to healthy Germans. We found a significant difference in PRNP129 genotype in dependence of the clinical predominance type of IPD. Patients with tremor-dominant IPD presented less frequent a methionine homozygosis at PRNP129 than hypokinetic-rigid IPD patients (30% versus 62.5%; p < 0.033). In conclusion, genotype distribution at codon 129 is obviously not essential in determining IPD. But our results may provide first evidence of an association between certain PRNP129 polymorphisms and the clinical presentation of IPD.
Details
Original language | English |
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Pages (from-to) | 331-337 |
Number of pages | 7 |
Journal | Journal of Neural Transmission |
Volume | 113 |
Issue number | 3 |
Publication status | Published - Mar 2006 |
Peer-reviewed | Yes |
External IDs
PubMed | 15997418 |
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Keywords
Sustainable Development Goals
ASJC Scopus subject areas
Keywords
- Codon 129, Creutzfeldt-Jakob disease, Neurogenetics, Parkinson's disease, Prion disease