Analysis of the Hamiltonian Monte Carlo genotyping algorithm on PROVEDIt mixtures including a novel precision benchmark
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
We provide an internal validation study of a recently published precise DNA mixture algorithm based on Hamiltonian Monte Carlo sampling (Susik et al., 2022). We provide results for all 428 mixtures analysed by Riman et al. (2021) and compare the results with two state-of-the-art software products: STRmix™ v2.6 and Euroformix v3.4.0. The comparison shows that the Hamiltonian Monte Carlo method provides reliable values of likelihood ratios (LRs) close to the other methods. We further propose a novel large-scale precision benchmark and quantify the precision of the Hamiltonian Monte Carlo method, indicating its improvements over existing solutions. Finally, we analyse the influence of the factors discussed by Buckleton et al. (2022).
Details
Original language | English |
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Article number | 102840 |
Number of pages | 13 |
Journal | Forensic Science International: Genetics |
Volume | 64 (2023) |
Early online date | 1 Feb 2023 |
Publication status | Published - May 2023 |
Peer-reviewed | Yes |
External IDs
PubMed | 36764220 |
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ORCID | /0000-0003-4414-4340/work/159608273 |
Keywords
ASJC Scopus subject areas
Keywords
- DNA mixtures, HMC, Probabilistic genotyping, Validation