The present study focuses on the Amundsen Sea sector which is the most dynamical region of the Antarctic Ice Sheet (AIS). Based on basin estimates of mass changes observed by the Gravity Recovery and Climate Experiment (GRACE) and volume changes observed by the Ice, Cloud and Land Elevation Satellite (ICESat), the mean mass change induced by Glacial Isostatic Adjustment (GIA) is derived. This mean GIA-induced mass change is found to be 34.1 ± 11.9 Gt/yr, which is significantly larger than the predictions of current GIA models. We show that the corresponding mean elevation change of 23.3 ± 7.7 mm/yr in the Amundsen Sea sector is in good agreement with the uplift rates obtained from observations at three GPS sites. Utilising ICESat observations, the observed uplift rates were corrected for elastic deformations due to present-day ice-mass changes. Based on the GRACE-derived mass change estimate and the inferred GIA correction, we inferred a present-day ice-mass loss of − 98.9 ± 13.7 Gt/yr for the Amundsen Sea sector. This is equivalent to a global eustatic sea-level rise of 0.27 ± 0.04 mm/yr. Compared to the results relying on GIA model predictions, this corresponds to an increase of the ice-mass loss or sea-level rise, respectively, of about 40%.