Altered functional connectivity in common resting-state networks in patients with major depressive disorder: A resting-state functional connectivity study

Research output: Contribution to journalResearch articleContributedpeer-review


  • Susann Krug - , Leibniz University Hannover (LUH) (Author)
  • Thomas J. Müller - , Private Hospital Meiringen, Meiringen, Switzerland (Author)
  • Özelem F. Kayali - , Leibniz University Hannover (LUH) (Author)
  • Eerik Leichter - , Leibniz University Hannover (LUH) (Author)
  • Stephanie K. V. Peschel - , Leibniz University Hannover (LUH) (Author)
  • Niklas Jahn - , Leibniz University Hannover (LUH) (Author)
  • Lotta Winter - , Leibniz University Hannover (LUH) (Author)
  • Tillmann H. C. Krüger - , University of Veterinary Medicine Hannover (Author)
  • K. G. Kahl - , Leibniz University Hannover (LUH) (Author)
  • Christopher Sinke - , University of Veterinary Medicine Hannover (Author)
  • Ivo Heitland - , Leibniz University Hannover (LUH) (Author)


The neural correlates of major depressive disorder (MDD) remain disputed. In the absence of reliable biological markers, the dysfunction and interaction of neural networks have been proposed as pathophysiological neural mechanisms in depression. Here, we examined the functional connectivity (FC) of brain networks. 51 healthy volunteers (mean age 33.57 ± 7.80) and 55 individuals diagnosed with MDD (mean age 33.89 ± 11.00) participated by performing a resting-state (rs) fMRI scan. Seed to voxel FC analyses were performed. Compared to healthy control (HC), MDD patients showed higher connectivity between the hippocampus and the anterior cingulate cortex (ACC) and lower connectivity between the insula and the ACC. The MDD group displayed lower connectivity between the inferior parietal lobule (IPL) and the superior frontal gyrus (SFG). The current data replicate previous findings regarding the cortico-limbic network (hippocampus - ACC connection) and the salience network (insula - ACC connection) and provide novel insight into altered rsFC in MDD, in particular involving the hippocampus - ACC and the insula - ACC connection. Furthermore, altered connectivity between the IPL and SFG indicates that the processing in higher cognitive processes such as attention and working memory is affected in MDD. These data further support dysfunctional neuronal networks as an interesting pathophysiological marker in depression.


Original languageEnglish
Pages (from-to)33-41
Number of pages9
JournalJournal of psychiatric research
Publication statusPublished - 1 Nov 2022
Externally publishedYes

External IDs

Scopus 85136015224
unpaywall 10.1016/j.jpsychires.2022.07.040
Mendeley 75c8a9a9-dae3-37fb-9737-e02e9f6703fa


Research priority areas of TU Dresden

Sustainable Development Goals


  • ACC, Hippocampus, Insula, Major depressive disorder, Resting-state functional connectivity networks, Superior frontal gyrus, Humans, Limbic System, Depressive Disorder, Major/diagnostic imaging, Young Adult, Brain/diagnostic imaging, Magnetic Resonance Imaging, Gyrus Cinguli, Brain Mapping, Adult

Library keywords